Search results for " Wissen"

showing 10 items of 52 documents

Sensitive Assays by Nucleophile-Induced Rearrangement of Photoactivated Diarylethenes.

2018

Upon light-induced isomerization, diarylethenes (DAEs) equipped with reactive aldehyde moieties rearrange selectively in the presence of amines, accompanied by decoloration. In a comprehensive study, the probe structure was optimized with regard to its inherent reactivity in the nucleophile-triggered rearrangement reaction. Detailed structure−reactivity relationships could be derived, in particular with regard to the type of integrated (het)aryl moieties as well as the location of the formyl residue, and the probes’ intrinsic reactivity with primary and secondary amines was optimized. Utilizing an ancillary base, the initially formed rearrangement product can engage in a subsequent catalyti…

010402 general chemistry01 natural sciencesBiochemistryAldehydeCatalysischemistry.chemical_compoundPhotochromismColloid and Surface ChemistryNucleophile541 Physikalische ChemieReactivity (chemistry)Rearrangement reactionsensingchemistry.chemical_classification010405 organic chemistryArylGeneral ChemistryphotochromismCombinatorial chemistry0104 chemical sciences540 Chemie und zugeordnete WissenschaftenaminechemistryCatalytic cycleddc:540diaryletheneddc:541547 Organische ChemieIsomerizationddc:547Journal of the American Chemical Society
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ARIA digital anamorphosis: Digital transformation of health and care in airway diseases from research to practice: Review

2020

Submitted by (omml@ubi.pt) on 2021-07-05T10:37:14Z No. of bitstreams: 1 2021_Bousquet J_A_Anamorphosis.pdf: 1897974 bytes, checksum: 918eb581ab4e940b055ef8514f960e28 (MD5) Approved for entry into archive by Pessoa (pfep@ubi.pt) on 2021-07-05T11:16:44Z (GMT) No. of bitstreams: 1 2021_Bousquet J_A_Anamorphosis.pdf: 1897974 bytes, checksum: 918eb581ab4e940b055ef8514f960e28 (MD5) Approved for entry into archive by Pessoa (pfep@ubi.pt) on 2021-07-05T11:20:07Z (GMT) No. of bitstreams: 1 2021_Bousquet J_A_Anamorphosis.pdf: 1897974 bytes, checksum: 918eb581ab4e940b055ef8514f960e28 (MD5) Made available in DSpace on 2021-07-05T11:20:07Z (GMT). No. of bitstreams: 1 2021_Bousquet J_A_Anamorphosis.pdf: …

0301 basic medicineAllergyCARATComputer scienceIMPACTRespiratory Medicine and Allergy[SDV]Life Sciences [q-bio]computer.software_genreMedical and Health SciencesChange management (ITSM)Rhinitis.0302 clinical medicineQUALITY-OF-LIFEHDE ALERImmunology and AllergyLungmedicin och allergiSelf-managementRhinitis AllergicMultimediaAnamorphosisMOBILE TECHNOLOGYWORK PRODUCTIVITYdigital transformation of health and care3. Good healthsmernice ARIAAirway disease1107 ImmunologyGA(2)LENLife Sciences & BiomedicineASTHMA MULTIMORBIDITYe-zdravje600 Technik Medizin angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und GesundheitARIA; asthma; CARAT; digital transformation of health and care; MASK; rhinitisSEASONAL ALLERGIC RHINITISMASKProcess (engineering)digital transformation of healthcareEUROPEAN INNOVATION PARTNERSHIPImmunologydigitalizacija zdravstvaARIA guidelines61003 medical and health sciencesQuality of life (healthcare)rhinitisHumansMobile technologyddc:610SELF-MANAGEMENTudc:616.2Science & TechnologyARIADigital transformationasthmaRespiration DisordersRhinitis AllergicMODEL030104 developmental biology030228 respiratory system3121 General medicine internal medicine and other clinical medicinee-healthClinical Medicinecomputer
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Models for preterm cortical development using non invasive clinical EEG

2017

AbstractThe objective of this study was to evaluate the piglet and the mouse as model systems for preterm cortical development. According to the clinical context, we used non invasive EEG recordings. As a prerequisite, we developed miniaturized Ag/AgCl electrodes for full band EEG recordings in mice and verified that Urethane had no effect on EEG band power. Since mice are born with a “preterm” brain, we evaluated three age groups: P0/P1, P3/P4 and P13/P14. Our aim was to identify EEG patterns in the somatosensory cortex which are distinguishable between developmental stages and represent a physiologic brain development. In mice, we were able to find clear differences between age groups wit…

0301 basic medicineBrain developmentsomatosensory cortexmouse modelContext (language use)Neurosciences. Biological psychiatry. NeuropsychiatryBiologyElectroencephalographySomatosensory system600 Technik Medizin angewandte Wissenschaften::610 Medizin und Gesundheit::616 KrankheitenInterhemispheric coherence03 medical and health sciences0302 clinical medicine616medicineCoherence (signal processing)cortical developmentmedicine.diagnostic_testGeneral Neurosciencephase amplitude couplingNon invasivetelemetrycoherence030104 developmental biologypigletfull band eegpretermNeuroscience030217 neurology & neurosurgeryPhase amplitude couplingRegular ArticlesRC321-571Translational Neuroscience
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Q-nexus: a comprehensive and efficient analysis pipeline designed for ChIP-nexus

2016

Background: ChIP-nexus, an extension of the ChIP-exo protocol, can be used to map the borders of protein-bound DNA sequences at nucleotide resolution, requires less input DNA and enables selective PCR duplicate removal using random barcodes. However, the use of random barcodes requires additional preprocessing of the mapping data, which complicates the computational analysis. To date, only a very limited number of software packages are available for the analysis of ChIP-exo data, which have not yet been systematically tested and compared on ChIP-nexus data. Results: Here, we present a comprehensive software package for ChIP-nexus data that exploits the random barcodes for selective removal …

0301 basic medicineFOS: Computer and information sciencesDuplication ratesChromatin ImmunoprecipitationBioinformaticsPipeline (computing)610Biologycomputer.software_genre600 Technik Medizin angewandte Wissenschaften::610 Medizin und Gesundheit03 medical and health sciencesSoftwareChIP-nexusGeneticsPreprocessorNucleotide MotifsLibrary complexityChIP-exoGeneticsProtocol (science)Binding Sitesbusiness.industryfungiComputational BiologyHigh-Throughput Nucleotide SequencingReproducibility of ResultsChipChromatin immunoprecipitationData mappingDNA-Binding ProteinsAlgorithm030104 developmental biologyChIP-exoData miningbusinessPeak callingcomputerAlgorithmsSoftwareProtein BindingTranscription FactorsResearch ArticleBiotechnologyBMC Genomics
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Human leukocyte antigen-E mismatch is associated with better hematopoietic stem cell transplantation outcome in acute leukemia patients

2017

The immunomodulatory role of human leukocyte antigen (HLA)-E in hematopoietic stem cell transplantation (HSCT) has not been extensively investigated. To this end, we genotyped 509 10/10 HLA unrelated transplant pairs for HLA-E, in order to study the effect of HLA-E as a natural killer (NK)-alloreactivity mediator on HSCT outcome in an acute leukemia (AL) setting. Overall survival (OS), disease free survival (DFS), relapse incidence (RI) and non-relapse mortality (NRM) were set as endpoints. Analysis of our data revealed a significant correlation between HLA-E mismatch and improved HSCT outcome, as shown by both univariate (53% vs. 38%, P=0.002, 5-year OS) and multivariate (hazard ratio (HR)…

0301 basic medicineOncologyAdultMalemedicine.medical_specialtyTransplantation ConditioningAdolescentGenotypemedicine.medical_treatment610Hematopoietic stem cell transplantationHuman leukocyte antigen600 Technik Medizin angewandte Wissenschaften::610 Medizin und GesundheitArticle03 medical and health sciencesYoung Adult0302 clinical medicineCell Therapy & ImmunotherapyInternal medicineMedicineHumansTransplantation Homologousddc:610Potassium Channels Inwardly RectifyingSurvival analysisAllelesAgedBone Marrow TransplantationAcute leukemiabusiness.industryDonor selectionHistocompatibility TestingHazard ratioHistocompatibility Antigens Class IHematopoietic Stem Cell TransplantationHematologyMiddle Agedmedicine.diseasePrognosisSurvival AnalysisTransplantationLeukemiaLeukemia Myeloid Acute030104 developmental biologyTreatment OutcomeImmunologyFemalebusiness030215 immunology
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Innovative Strategies to Develop Chemical Categories Using a Combination of Structural and Toxicological Properties.

2016

Interest is increasing in the development of non-animal methods for toxicological evaluations. These methods are however, particularly challenging for complex toxicological endpoints such as repeated dose toxicity. European Legislation, e.g., the European Union's Cosmetic Directive and REACH, demands the use of alternative methods. Frameworks, such as the Read-across Assessment Framework or the Adverse Outcome Pathway Knowledge Base, support the development of these methods. The aim of the project presented in this publication was to develop substance categories for a read-across with complex endpoints of toxicity based on existing databases. The basic conceptual approach was to combine str…

0301 basic medicineQuantitative structure–activity relationshipread acrossPredictive Clustering Tree (PCT) methodComputer science610010501 environmental sciencescomputer.software_genre600 Technik Medizin angewandte Wissenschaften::610 Medizin und Gesundheit01 natural sciences03 medical and health sciencesPharmacology (medical)Cluster analysis0105 earth and related environmental sciencesOriginal ResearchAlternative methodsPharmacologytoxicological and structural similaritybusiness.industryQSARlcsh:RM1-950non-animal methods; QSAR; readacross; Predictive Clustering Tree (PCT) method; toxicological and structural similarityIdentification (information)Tree (data structure)030104 developmental biologyConceptual approachlcsh:Therapeutics. PharmacologyKnowledge basenon-animal methodsData miningWeb servicebusinesscomputerFrontiers in pharmacology
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ARIA���EAACI statement on asthma and COVID���19 (June 2, 2020)

2021

Artículo con numerosos autores sólo se mencionan el primero y el de la UAM

2019-20 coronavirus outbreakCoronavirus disease 2019 (COVID-19)AllergyStatement (logic)MedicinaSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)virusesImmunology610Settore MED/10 - Malattie Dell'Apparato Respiratoriomedicine.disease_cause03 medical and health sciences0302 clinical medicineastmaMedicine and Health SciencesmedicineHumansImmunology and Allergy030212 general & internal medicineLetters to the EditorLetter to the Editorudc:616.2AsthmaCoronavirusScience & Technologybusiness.industrySARS-CoV-2virus diseasesCOVID-19asthmamedicine.diseaseVirologyAsthma3. Good health030228 respiratory systemcovid-191107 ImmunologyAngiotensin-Converting Enzyme 2businessARIA-EAACILife Sciences & Biomedicine600 Technik Medizin angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
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Focal Cortical Lesions Induce Bidirectional Changes in the Excitability of Fast Spiking and Non Fast Spiking Cortical Interneurons

2014

A physiological brain function requires neuronal networks to operate within a well-defined range of activity. Indeed, alterations in neuronal excitability have been associated with several pathological conditions, ranging from epilepsy to neuropsychiatric disorders. Changes in inhibitory transmission are known to play a key role in the development of hyperexcitability. However it is largely unknown whether specific interneuronal subpopulations contribute differentially to such pathological condition. In the present study we investigated functional alterations of inhibitory interneurons embedded in a hyperexcitable cortical circuit at the border of chronically induced focal lesions in mouse …

500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie570Neural NetworksPostsynaptic CurrentExcitotoxicity610lcsh:MedicineNeurophysiologyAction PotentialsNeural Homeostasis600 Technik Medizin angewandte Wissenschaften::610 Medizin und Gesundheitmedicine.disease_causeInhibitory postsynaptic potentialMiceEpilepsyInterneuronsmedicineBiological neural networkAnimalslcsh:ScienceVisual CortexCerebral CortexMembrane potentialMultidisciplinarymusculoskeletal neural and ocular physiologylcsh:RNeurotransmissionBiology and Life SciencesExcitatory Postsynaptic Potentialsmedicine.diseaseVisual cortexmedicine.anatomical_structurenervous systemCellular NeuroscienceExcitatory postsynaptic potentiallcsh:QNeuroscienceResearch ArticleNeurosciencePLoS ONE
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Polyester microplastic fibers affect soil physical properties and erosion as a function of soil type

2021

Microplastics are recognized as a factor of global change contaminating many environmental compartments. Agricultural soils are very likely to receive microplastic contamination and are of particular concern due to their role in food production. Microplastic fibers have already been shown to be able to affect soil properties, but their effect on different soil types is poorly understood. Moreover, limited information is available on how the presence of this pollutant can affect soil water erosion processes, which are extremely important issues in many environments. In the light of this, we performed two experiments (carried out on a microscale) to investigate how the presence of polyester m…

570soil erosion600 Technik Medizin angewandte Wissenschaften::630 Landwirtschaft::630 Landwirtschaft und verwandte Bereiche550Microplastic in soil500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie::570 Biowissenschaften; Biologieerosioncomplex mixtures630Settore AGR/02 - Agronomia E Coltivazioni ErbaceePolyester microplasticsoil typesoil propertiessoil physical properties500 Naturwissenschaften und Mathematik::550 Geowissenschaften Geologie::550 GeowissenschaftenSettore AGR/08 - Idraulica Agraria E Sistemazioni Idraulico-Forestali
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Broadband Multi-wavelength Properties of M87 during the 2017 Event Horizon Telescope Campaign

2021

Full list of authors: EHT MWL Science Working Group; Algaba, J. C.; Anczarski, J.; Asada, K.; Baloković, M.; Chandra, S.; Cui, Y. -Z.; Falcone, A. D.; Giroletti, M.; Goddi, C.; Hada, K.; Haggard, D.; Jorstad, S.; Kaur, A.; Kawashima, T.; Keating, G.; Kim, J. -Y.; Kino, M.; Komossa, S.; Kravchenko, E. V.; Krichbaum, T. P.; Lee, S. -S.; Lu, R. -S.; Lucchini, M.; Markoff, S.; Neilsen, J.; Nowak, M. A.; Park, J.; Principe, G.; Ramakrishnan, V.; Reynolds, M. T.; Sasada, M.; Savchenko, S. S.; Williamson, K. E.; Event Horizon Telescope Collaboration; Akiyama, Kazunori; Alberdi, Antxon; Alef, Walter; Anantua, Richard; Azulay, Rebecca; Baczko, Anne-Kathrin; Ball, David; Barrett, John; Bintley, Dan; …

Accretion010504 meteorology & atmospheric sciencesAstronomyFluxAstrophysics7. Clean energy01 natural sciencesActive galactic nuclei; Radio cores; Low-luminosity active galactic nuclei; High energy astrophysics; Astrophysical black holes; Accretion; Astrophysics - High Energy Astrophysical Phenomena; Astrophysics - Cosmology and Nongalactic Astrophysics; Astrophysics - Astrophysics of Galaxies010303 astronomy & astrophysicsHigh Energy Astrophysical Phenomena (astro-ph.HE)Physicsastro-ph.HERadio coreAccretion (meteorology)PhysicsAstrophysical black holes520 Astronomie und zugeordnete WissenschaftenActive galactic nuclei ; Radio cores ; Low-luminosity ; active galactic nuclei ; High energy astrophysics ; Astrophysical black holes ; AccretionAstrophysical black holeLow-luminosity active galactic nucleiastro-ph.COAstrophysics - High Energy Astrophysical PhenomenaAccretion; Active galactic nuclei; Astrophysical black holes; High energy astrophysics; Low-luminosity active galactic nuclei; Radio coresHigh energy astrophysicsRadio coresAstrophysics - Cosmology and Nongalactic AstrophysicsCosmology and Nongalactic Astrophysics (astro-ph.CO)Active galactic nucleusHigh-energy astronomyastro-ph.GAAstrophysics::High Energy Astrophysical PhenomenaFOS: Physical sciencesF500Astrophysics::Cosmology and Extragalactic AstrophysicsHigh energy astrophysic0103 physical sciencesVery-long-baseline interferometryddc:530Astrophysics::Galaxy Astrophysics0105 earth and related environmental sciencesEvent Horizon TelescopeSupermassive black holeActive galactic nucleiAstronomy and Astrophysics530 PhysikAstrophysics - Astrophysics of GalaxiesGalaxySpace and Planetary ScienceAstrophysics of Galaxies (astro-ph.GA)ddc:520Active galactic nuclei; Radio cores; Low-luminosity active galactic nuclei; High energy astrophysics; Astrophysical black holes; AccretionHESS - Abteilung Hinton[PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph]
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